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Begin Covid-19 vaccine trials for children, pediatric specialists say

The CDC on Monday abruptly reverted to its previous guidance about how coronavirus is transmitted, removing language about airborne transmission it had posted just days earlier. CNN's Elizabeth Cohen tells us more.

Posted: Sep 21, 2020 10:51 AM
Updated: Sep 22, 2020 9:00 PM


With the US surpassing 200,000 deaths due to Covid-19, a group of pediatric infectious disease specialists is calling for vaccine trials for children.

There are three large-scale vaccine trials for adults in the US, but none has begun for children, who are 'stuck in neutral,' eight physicians said in a commentary published Friday in the medical journal Clinical Infectious Diseases.

'Even though things are moving at unprecedented speed for adults and older adults for Covid-19 vaccines, we haven't yet made inroads to have pediatric trials starting,' said Dr. Buddy Creech, a pediatric infectious disease specialist at Vanderbilt University and one of the authors of the commentary.

'This is really a call to say rather than waiting to see if we have an effective vaccine for adults, let's begin that work of at least evaluating the vaccines in adolescents and ever-decreasing ages, so that we get a good bead on the dosing, the dose schedule, and the potential effectiveness of that kind of a vaccine,' Creech said.

Pfizer, who is in the last phase of trials for its vaccine, is 'working actively with regulators on a potential pediatric study plan,' a spokesperson for the company told CNN.

Moderna, another company with a vaccine in Phase 3 trials in the US, plans to start pediatric trials 'in the near future, subject to regulatory approval,' a spokesperson said in a statement to CNN.

So far, more than 6.89 million Americans have been infected since the start of the pandemic and at least 200,710 have died, according to Johns Hopkins Universit

FDA considering measures that would put vaccine well past Election Day

The US Food and Drug Administration is considering new rules for emergency authorization of a Covid-19 vaccine that would push authorization beyond Election Day, according to three sources familiar with the situation.

The sources described two different scenarios that the FDA is assessing before a pharmacy company can be given an emergency use authorization for its vaccine.

'Either way, it's going to be Thanksgiving at the earliest before a company gets an EUA,' or emergency use authorization, the first source said.

One source said the FDA is expected to require vaccine makers to wait two months after giving all their study participants in Phase 3 trials their second doses of the vaccine before applying for authorization.

A second source, a senior administration official, said the agency is expected to require that companies wait 60 days after giving half their trial participants their second dose before the vaccine can be authorized.

The move is designed to monitor the safety of the vaccine, even if the trial has already determined the vaccine's efficacy.

The country should have good data on the safety and effectiveness of a vaccine sometime in November, Dr. Ashish Jha told the US Joint Economic Committee Tuesday, adding he believes there will be a vaccine before the end of the year.

Jha, dean of Brown University's public health school, said he has been 'immensely supportive' of Operation Warp Speed, the White House's efforts to speed up the production of vaccines and Covid-19 treatments.

'I think that's been the right thing to do, because once we have the evidence of safety and efficacy we will not want to wait,' Jha said.

A recent poll from the Kaiser Family Foundation found that more than half of respondents -- 54% -- said they would not get the vaccine if it was available for free before the November 3 presidential election. Along party lines, 60% of Republicans and 56% of independents said they would not. Half of Democrats said they would.

Fauci: Country's division is hampering the messaging

The country's current divided state is one of the things that's getting in the way of clear and consistent messaging when it comes to Covid-19 in the US is the country's current divided state, Dr. Anthony Fauci said.

'We are in such a divisive state in society that it tends to get politicized,' the country's leading infectious disease expert said Monday night on 'The Daily Show with Trevor Noah.'

'It's almost the one side versus the other,' Fauci said.

The US is now months-deep into navigating the Covid-19 pandemic and several safety measures remain points of contention -- including face masks. While many across the country have embraced experts' recommendations to wear face coverings to protect against the virus' spread, others have protested their use.

'People take sides, like wearing a mask or not is a political statement and that's really unfortunate, totally unfortunate because this is a purely public health issue. It should not be one against the other,' Fauci said.

But even Americans who want to follow guidance from experts about Covid-19 ran into a muddied message this week. The US Centers for Disease Control and Prevention updated its guidance to say Covid-19 can spread through the air but days later abruptly reverted back to guidance posted months ago -- saying the virus is thought to spread mainly between people in close contact and 'through respiratory droplets produced when an infected person coughs, sneezes or talks.'

Several studies have shown the virus can spread through small particles in the air.

'It's extremely confusing,' Dr. Leana Wen, a CNN medical analyst and emergency medicine physician at George Washington University, told CNN. 'And that type of whiplash -- especially without an explanation directly from the CDC -- creates confusion and unfortunately leads to lack of trust in the CDC overall.'

How confusion could contribute to spike

With fall rolling in, the US is heading into what CDC Director Dr. Robert Redfield predicted could be one of the 'most difficult times' in American public health. One expert told CNN this week the next months may make for an 'apocalyptic fall.'

'It's happening because we're forcing schools to reopen in areas of high transmission,' said Dr. Peter Hotez, dean of the National School of Tropical Medicine at Baylor College of Medicine. 'We're forcing colleges to reopen, and we don't have the leadership nationally, telling people to wear masks and to social distance and do all the things we need to do.'

The US could see another surge of cases and that surge could come on top of flu season, which health officials have warned could complicate things -- greatly. At least 24 states are now reporting an uptick in new cases compared to the previous week, according to data from Johns Hopkins University -- many of them across America's heartland and Midwest.

Why?

Dr. Jeanne Marrazzo, an infectious diseases expert at the University of Alabama at Birmingham, says there are several factors that could be contributing to the rise in numbers -- including the public's fatigue of pandemic-like conditions.

'And then the second thing is ... the completely contradictory messages that we're getting -- not just the misinformation, but also the confusion about how things are spread.'

More than 4,000 students and school staff infected in Texas

A rise in cases also comes after many students across the country returned to class -- both in schools and colleges.

Colleges and universities across all 50 states have reported infections -- prompting local leaders to set new measures in place in hopes of controlling the spread of the virus on college campuses and in college towns.

Infections have increased among younger students as well -- and those around them.

In Texas, there have been more than 4,500 positive cases of Covid-19 among students and staff in the state's public schools since the new academic year kicked off, according to data from the Texas Education Agency.

More than 2,300 of those cases are students.

In Florida, the number of children under 18 who have contracted the virus has jumped 26% since many of the state's public schools opened.

Experts are still studying the role children play in the transmission of the virus but several studies have shown they can spread it too -- often, just as much as adults.

And a report recently released by the CDC suggests that not only can children spread the virus but they can do so even when they show mild symptoms or none at all.

California Coronavirus Cases

Data is updated nightly.

Confirmed Cases: 879645

Reported Deaths: 16982
CountyConfirmedDeaths
Los Angeles2893666877
Riverside640751272
San Bernardino597791021
Orange570711410
San Diego52735853
Kern33448410
Fresno30051429
Sacramento24425468
Santa Clara23355378
Alameda22738433
San Joaquin21187484
Contra Costa18157234
Stanislaus17341392
Tulare17120275
Ventura13901160
Imperial12475335
San Francisco11901133
Monterey1109183
San Mateo10810157
Santa Barbara9608119
Merced9314152
Sonoma8934129
Kings815983
Solano711774
Marin7019124
Madera488673
San Luis Obispo400932
Placer397852
Yolo307356
Butte301950
Santa Cruz270623
Napa188214
Sutter179612
Shasta172329
San Benito140314
El Dorado12834
Yuba125310
Mendocino110321
Tehama7748
Lassen7571
Lake67015
Glenn6393
Nevada5828
Humboldt5549
Colusa5456
Calaveras33317
Amador31316
Tuolumne2494
Inyo21515
Siskiyou1840
Mono1752
Del Norte1731
Mariposa782
Plumas540
Modoc270
Trinity230
Sierra60
Alpine30
Unassigned00
Chico
Few Clouds
84° wxIcon
Hi: 93° Lo: 57°
Feels Like: 84°
Oroville
Clear
79° wxIcon
Hi: 89° Lo: 57°
Feels Like: 79°
Paradise
Few Clouds
84° wxIcon
Hi: 86° Lo: 60°
Feels Like: 84°
Chester
Clear
59° wxIcon
Hi: 75° Lo: 45°
Feels Like: 59°
Red Bluff
Clear
86° wxIcon
Hi: 95° Lo: 63°
Feels Like: 86°
Willows
Few Clouds
84° wxIcon
Hi: 96° Lo: 59°
Feels Like: 84°
Tuesday was another sunny and unseasonably warm to hot day for much of northern California. It was much like Monday, except the wind was stronger, and the wind will be much stronger through much of the next week.
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