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Pfizer proposes expanding Covid-19 vaccine trial to include more diversity as race for a vaccine continues

CNN Chief Medical Correspondent Dr. Sanjay Gupta sat down with Operation Warp Speed chief adviser Dr. Moncef Slaoui and asked him about the timeline for the coronavirus vaccine.

Posted: Sep 13, 2020 11:01 PM
Updated: Sep 13, 2020 11:01 PM

The race for a coronavirus vaccine shows no signs of slowing as more companies move their vaccine candidates through clinical trials, growing closer to determining which will be considered safe and effective.

One such candidate is in development by the American pharmaceutical company Pfizer, which announced along with its German partner BioNTech on Saturday they proposed expanding Phase 3 clinical trials to include 44,000 participants and more diverse patient populations, including people as young as 16.

That's up from the initial plan of 30,000 participants, a benchmark they plan to meet next week, according to a news release.

The proposal, which would need approval by the Food and Drug Administration, would allow the companies to collect more data on the safety and efficacy of the vaccine candidate while diversifying the pool of participants.

"I think we should strive to have as more diverse population as possible," Pfizer CEO Albert Bourla told CBS on "Face the Nation" Sunday, stressing the importance of having a diverse group of volunteers given the heightened impact Covid-19 has had on communities of color.

"But right now we are not bad. Actually, we have a population that globally only 60% are Caucasians, 40%, approximately, minorities," he said.

Bourla told CBS that there was a "quite good chance" that the team testing the vaccine candidate will know whether it works by the end of October. But when asked if people would have to wait until 2021 to get the vaccine, Bourla said he didn't know how long it could take for regulators to approve it.

Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases -- which is working on its own vaccine candidate with Moderna -- said Friday he remains "cautiously optimistic" that a vaccine will be ready by the end of the year.

But meeting the high demand will present its own logistic challenges, and Fauci said life is unlikely to return to normal before 2021.

"It's not going to be turning a switch off and turning the switch on," he told CNN's Wolf Blitzer. "It's going to be gradual and I think it's going to take several months before we get to the point where we can really feel something that approximates how it was normally before Covid-19."

As of Sunday, more than 6.5 million cases of coronavirus have been reported in the United States, according to data from Johns Hopkins University. More than 194,000 people have died.

35 vaccines in human trials

The fact that finding a coronavirus vaccine is so critical has led to an accelerated timeline for vaccine development, leading to some concerns over safety.

Earlier this week, nine companies signed a safety pledge promising they would not seek premature approval for a vaccine, and Dr. Fauci has reiterated that Americans should have confidence in the approval process.

There are 35 vaccines in human trials around the world. Eight are in late-stage, large clinical trials as of Friday, per the World Health Organization, including Pfizer's and a candidate by AstraZeneca and the University of Oxford, which announced its trial would resume in the United Kingdom after being halted last week following an unexplained illness in one of the volunteers -- a step experts said is not unprecedented.

"In large trials such as this, it is expected that some participants will become unwell and every case must be carefully evaluated to ensure careful assessment of safety," Oxford said in a statement.

Pausing a vaccine trial is a standard precaution, US National Institutes of Health Director Dr. Francis Collins told a Senate hearing Wednesday. He said it's meant to ensure experimental vaccines don't cause serious reactions.

College towns struggle after fall semester begins

While many colleges have moved classes online, that hasn't necessarily stopped students from gathering. And now some college towns are grappling with outbreaks of Covid-19 as the start of the fall semester complicates local responses to the pandemic.

"We are urging students to understand the imperative role that they play in stopping this community spread and, ultimately, saving lives," said Aaron Stephens, mayor of East Lansing, Michigan, where Michigan State University students were asked to quarantine after the local health department reported 342 new cases among people affiliated with the university since August 24.

"MSU is committed to doing everything we can to prevent the spread of COVID-19," MSU Physician David Weismantel said. "The safety of our entire community is a priority and we all have a role to play in preventing the spread of the virus."

Kelly Girtz, the mayor of Athens-Clarke County, Georgia -- home to the University of Georgia -- told CNN Saturday his city has seen a "dramatic spike" in cases after maintaining lower case counts and death counts throughout the summer. UGA classes began August 20.

"Clearly, it's the return to campus of large numbers of students who are not here through the summertime," he said.

Six students at Miami University in Ohio were cited after holding a house party even though at least one of them tested positive for Covid-19, according to police records. The university declined to comment, citing federal privacy laws, but said students would face disciplinary action if they violate quarantine orders or the city ordinance on mass gatherings.

California Coronavirus Cases

Data is updated nightly.

Cases: 3563578

Reported Deaths: 51953
CountyCasesDeaths
Los Angeles119089421328
Riverside2894503767
San Bernardino2862912816
Orange2610223904
San Diego2596413271
Santa Clara1104221777
Kern102627826
Fresno952021443
Sacramento931801472
Alameda804961241
Ventura77534844
San Joaquin665691101
Contra Costa62164674
Stanislaus56024946
Tulare47784758
Monterey42138328
San Mateo38922515
San Francisco34213410
Santa Barbara31763409
Solano30024164
Merced28915397
Sonoma28063298
Imperial26888591
Kings21951218
Placer19763232
San Luis Obispo19612227
Madera15436209
Santa Cruz14588183
Marin13136197
Yolo12816185
Shasta10972174
Butte10941160
El Dorado9095100
Napa901469
Sutter884597
San Benito575959
Yuba573336
Lassen560119
Tehama508152
Nevada395274
Tuolumne394659
Mendocino379643
Amador345741
Humboldt318033
Lake315341
Glenn222023
Colusa212813
Calaveras190547
Siskiyou174014
Inyo128737
Mono12114
Del Norte9875
Plumas6536
Modoc4524
Mariposa3957
Trinity3675
Sierra990
Alpine810
Unassigned00
Chico
Partly Cloudy
63° wxIcon
Hi: 70° Lo: 36°
Feels Like: 63°
Oroville
Clear
59° wxIcon
Hi: 65° Lo: 48°
Feels Like: 59°
Chico
Partly Cloudy
63° wxIcon
Hi: 61° Lo: 44°
Feels Like: 63°
Red Bluff
Clear
70° wxIcon
Hi: 46° Lo: 16°
Feels Like: 70°
Red Bluff
Clear
65° wxIcon
Hi: 67° Lo: 43°
Feels Like: 65°
Chico
Clear
63° wxIcon
Hi: 72° Lo: 44°
Feels Like: 63°
After a windy Saturday and fairly breezy Sunday, the wind we've had is weakening as the month of February comes to a close. We can expect a mostly clear first morning of March, followed by more clouds and mild air by the afternoon.
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